Focus on my research...
Seven years of basic research in molecular and cellular biology allowed me to acquire deep knowledge in different scientific topics. Presented in my publications below.



The proteasome
J Biol Chem.(1993)


Pleiotropic drug resistance
Mol Microbiol. (2002)
EMBO J. (1998)
FEBS Lett. (1997)
J Cell Biol. (1997)
J Biol Chem. (1996)
J Biol Chem. (1996)
Mol Microbiol. (1996)
Mol Cell Biol. (1995)
Mol Cell Biol. (1994)


Signal transduction
J Cell Sci. (2000)
FEBS Lett. (2000)
The yeast proteasome
The proteasome is a multicatalytic proteinase complex playing a crucial role for the degradation of cytosolic proteins and represents together with the lysosome the major mecanism of proteolysis. Ubiquitin-labelled proteins are subjected to degradation by the proteasome through its three proteolytic activities.
   
Pleiotropic Drug Resistance
Pleiotropic Drug Resistance (PDR) is a phenomenon shown by some mammalian tumors that acquire resistance to a variety of different drugs which represents a serious obstacle to tumor treatment by chemotherapy. In yeast, the increased resistance towards cytotoxic agents is mediated by a network of transcription factors and their target genes encoding for membrane proteins of the family of ABC (ATP binding cassette) transporters. Those proteins are pumps which use the energy from ATP hydrolysis to export their substrats against a concentration gradient.
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Signal transduction
The destiny of a cell is regulated by its environnement which determines if the cell will die, divide or differentiate. The transduction of the extracellular signal through the binding of a growth factor to its transmembrane receptor can stimulate cell proliferation. Signal transduction implies a network of proteins which will finally lead to a differential gene expression in the nucleus. Proteins of the class of GTPases play a crucial role in this mecanism.
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